Administer Aranesp once every 2 weeks in patients who were receiving epoetin alfa once weekly. Hgb < 10 gm/dl Correct or exclude other causes of anemia (e.g., vitamin deficiency, metabolic or chronic inflammatory conditions, bleeding, etc.) Control hypertension prior to initiating and during treatment with Aranesp or EPOGEN. No significant clinical decisions should be made based on these images from this website without first consulting with a board-certified attending physician. In patients who are receiving epoetin alfa once weekly, darbepoetin should be administered once every 2 weeks. Administration Subcutaneously in either the abdomen, thigh, or hip (or upper arm if not self-injected). in two ways: 1) Hgb levels > 12 g/dL or 2) an increase The majority of patients with CKD will require supplemental iron during the course of ESA therapy. Do not use RETACRIT that has been shaken or frozen. Peripheral blood progenitor cell (PBPC) collection: 10 mcg/kg/day or 5-8 mcg/kg twice daily in donors. The recommended starting dose for adult patients is 50 to 100 Units/kg 3 times weekly intravenously or subcutaneously. Do not use any vials exhibiting particulate matter or discoloration. Adjust dose as follows to achieve and maintain a target hemoglobin: Inadequate response: Hemoglobin increases <1 g/dL after 6 weeks of therapy: Increase dose to 4.5 mcg/kg. Splenic Rupture RARE CASES OF SPLENIC RUPTURE HAVE BEEN REPORTED FOLLOWING THE ADMINISTRATION OF NEULASTA. Conversion of IV to SC EPO: a. Darbepoetin's T1/2 is approximately 3 times that of epoetin alfa. Evaluate the iron status in all patients before and during treatment. Medically reviewed by Drugs.com. %%EOF In pregnant women, lactating women, neonates, and infants use only single-dose vials (the benzyl alcohol-free formulation). Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. In order to be included in the DUE, Please review the latest applicable package insert for additional information and possible updates. Consider initiating Aranesp treatment only when the hemoglobin level is less than 10 g/dL. Initiate Aranesp in patients on cancer chemotherapy only if the hemoglobin is less than 10 g/dL, and if there is a minimum of two additional months of planned chemotherapy. ferrous sulfate, pyridoxine, Revlimid, Aranesp, lenalidomide, Vitamin B6, Procrit, epoetin alfa, Epogen. Please try after some time.Get new journal Tables of Contents sent right to your email inbox View important dosing Obviously, everyone pays a different price, so when you talk about the cost of a drug at a given dose, you're always talking at least a little bit inaccurately, because most of your audience will be paying a slightly different price.Given the current choices (and now different Medicare-reimbursement standards) for erythropoietic stimulation, how do physicians make their treatment decisions?When asked about Procrit vs. Aranesp, Michael S. Gordon, MD, Associate Dean for Research at the University College of Medicine, Phoenix Campus, and Associate Director of the Arizona Cancer CenterGreater Phoenix Area, responded, What physicians always want is (1) a drug that works, or is better than, the standard that they have available; and (2) a drug that has fewer side effects or impacts their patients' quality of life less than the standard. The recommended starting dose for pediatric patients (ages 1 month or older) is 50 Units/kg 3 times weekly intravenously or subcutaneously. 0 Physicians and patients should weigh the possible benefits of decreasing transfusions against the increased risks of death and other serious cardiovascular adverse reactions [see Boxed Warning and Clinical Studies (14)]. (0.6MB), Anemia Assessment and Management Brochure, Pathophysiology of Anemia in Patients with CKD, * Case studies and patient profiles are hypothetical, WARNING: ESAs INCREASE THE RISK OF DEATH, MYOCARDIAL INFARCTION, STROKE, VENOUS THROMBOEMBOLISM, THROMBOSIS OF VASCULAR ACCESS AND TUMOR PROGRESSION OR RECURRENCE. Rounding doses to the nearest vial size often enhances patient convenience and reduces costs without compromising clinical response. >/@tCh;6|{rf9V8&Wb~%l7JNCcoi AkrJ.ttbdq5QSu+r|0&OhF]{.r!r SN:]AW&g{auwi(D)Si'(EK 9P$a8d_R/au&tIk=[A'"Uh 5E~"{dC4dMs/*e?&Io}a\d05zVJ)~OL:MK'tiM>)r4zoBp`Vju`'78f4*q-PFa_,R2(r\?ASM^B6DT&s+IfUSqS6H5l~b)lMx:'j_sT[.q"ju g/8f5>tWw]}vAQNK0: st3pYBMf7m\tHC6l#C(!%J[l6(d/$Apx>GW mo^6*{INX%!ZuH@=_c Drug class: Recombinant human erythropoietins. If the hemoglobin level approaches or exceeds 11 g/dL, reduce or interrupt the dose of RETACRIT. number of patients receiving transfusions, to increase hemoglobin Copyright 2021 GlobalRPH - Web Development by, HONcode standard for trust- worthy health, Pediatric Oncology: Diagnosis And Prognosis Communication. Discontinue RETACRIT if an increase in hemoglobin is not achieved at a dose of 300 Units/kg for 8 weeks. Severe sickle cell crises, in some cases resulting in death, have also been associated with Filgrastim, the parent compound of pegfilgrastim. Pharmacotherapy JKn&,&LzN 1 0 obj Increase monitoring of these patients for changes in seizure frequency or premonitory symptoms (5.4). AZT-treated, HIV infected patients: 100 units/kg IV/SC 3 times/week x 8 weeks. PRCA: If severe anemia and low reticulocyte count develop during Aranesp treatment, withhold Aranesp and evaluate for PRCA (5.7). 335 0 obj <>stream <> The needle cover of the prefilled syringe contains dry natural rubber (a derivative of latex), which may cause allergic reactions. Please click to see accompanying Aranesp full prescribing information and EPOGEN full prescribing information, including Boxed WARNINGS and Medication Guide. Alternative dose: 600 units/kg in once weekly doses (21, 14, and 7 days before surgery) plus a fourth dose on the day of surgery. 1091 0 obj <> endobj Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration. %PDF-1.6 % For adult patients with CKD not on dialysis: When treating patients who have chronic kidney disease and cancer, physicians should refer to Warnings and Precautions (5.1 and 5.2). 2017 Jun 30;4:2054358117716461. doi: 10.1177/2054358117716461. 11 in the epoetin alfa-treated group and 7 in the darbepoetin alfa-treated IV Generic name: DARBEPOETIN ALFA 10ug in 0.4mL similar over the course of therapy for both groups. Estimated Aranesp Starting Doses (mcg/week) for Patients with CKD on Dialysis Based on Previous Epoetin alfa Dose (Units/week), Previous Weekly Epoetin alfa Dose (Units/week). Overall, in Drug class: recombinant human erythropoietins, Aranesp (Darbepoetin Alfa Prefilled Syringes), Anemia Associated with Chronic Renal Failure, If hemoglobin exceeds a level needed to avoid RBC transfusion, If hemoglobin increases by less than 1 g/dL. 300 Units/kg per day subcutaneously for 15 days total: administered daily for 10 days before surgery, on the day of surgery, and for 4 days after surgery. Apo-fluticasone Over The Counter Sumycin, deemed epoetin alfa (Procrit; OrthoBiotech) and darbepoetin Use the lowest dose of Aranesp necessary to avoid RBC transfusions. The recommended starting dose is 0.45 mcg/kg body weight intravenously or subcutaneously given once at four week intervals as appropriate. The conversion rate was 354:1 in patients requiring high (>200 IU/kg/week) doses of epoetin and 291:1 in patients requiring low doses. Do not use Aranesp that has been shaken or frozen. Based on the patient's response, darbepoetin 1.2 Patients with Acute Myeloid Leukemia Receiving Induction or Consolidation Chemotherapy ZARXIO is indicated for reducing the time to neutrophil recovery and the duration of fever, following induction or consolidation chemotherapy treatment of patients with acute myeloid leukemia (AML) [see Clinical Studies (14.2)]. Physician attestation that the patient is undergoing palliative treatment, AND 3. Procedure: Coverage of Erythropoiesis stimulating agents will be reviewed prospectively via the prior authorization endobj Use the lowest dose of RETACRIT necessary to avoid RBC transfusions. 1022 0 obj Discard unused portions of RETACRIT in preservative-free vials. 7/2021: added Epogen (nonformulary). Learn how to combine multiple dosing options for precise titration and individualize anemia management.1. In controlled clinical trials, ESAs increased the risk of death in patients undergoing coronary artery bypass graft surgery (CABG) and the risk of deep venous thrombosis (DVT) in patients undergoing orthopedic procedures. Patient Name_____ NKC#_____ Revised 01/14/2016 Page 1 of 4. doses. Discontinue the drug at least 48 hours before beginning the next cycle of chemotherapy. As a substitute for RBC transfusions in patients who require immediate correction of anemia. 3 0 obj *. Available for Android and iOS devices. For lack or loss of hemoglobin response to Aranesp or EPOGEN, initiate a search for causative factors. Although these images are curated, as they are sourced from the community, there is no way to guarantee a consistent standard of accuracy and quality across the library of images. OK Aranesp and EPOGEN have not been shown to improve quality of life, fatigue, or patient well-being. Nephrologists are also very divided on whether it is easy to switch between long-acting ESAs (such as Amgen's Aranesp and Roche/Vifor's Mircera) and short-acting ESAs (such as Epogen and Retacrit . PHYSICIAN INFORMATION PATIENT INFORMATION * Physician Name: *Due to privacy regulations we will not be able to respond via fax with the outcome of our review unless all asterisked (*) items on this * DEA, NPI or TIN: form are completed. of darbepoetin administered SC has been shown in cancer patients Isotretinoin For Acne Herbolax, Epub 2004 Feb 19.Hymes J, Bickimer T, Jackson JH, Bookhart BK, Mody SH, Tak Piech C.Curr Med Res Opin. If a serious allergic reaction occurs, appropriate therapy should be administered, with close patient follow-up over several days. both groups iron studies were not conducted routinely. Aranesp, Epogen, Mircera, Procrit, Retacrit . Adults: 50 mcg/kg once daily for 10-21 days (until postnadir platelet count >/= 50,000 cells/uL). Dr. Gerald Diaz @GeraldMD 5 years ago. Individualize dosing and use the lowest dose of RETACRIT sufficient to reduce the need for RBC transfusions [see Warnings and Precautions (5.1)]. Dosage adjustment: Goal: Dose should be adjusted to achieve and maintain a target hemoglobin not to exceed 12 g/dL. %PDF-1.6 % Medication Guide Spokespersons from NCI were not available for comment at press time.Dr. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration. If the hemoglobin level approaches or exceeds 11 g/dL, reduce or interrupt the dose of Aranesp. Cancel, Aranesp (darbepoetin alfa) Prescribing Information, EPOGEN (epoetin alfa) Prescribing Information, Aranesp and EPOGEN Important Safety Information, Prescribing Information, Important Safety Information, Dosing Information and Indications, DOWNLOAD ARANESP PRESCRIBING INFORMATION. f'H""=1` 0LHb0[!= d ]L,~a`t/ BS Trimethoprim/sulfamethoxazole Super P-force, for epoetin alfa-treated patients and 200 mcg every 2 weeks (or In cancer patients, erythropoietic agents, including The majority of patients with CKD will require supplemental iron during the course of ESA therapy. In CKD, for subcutaneous (SC) administration Clindamycin BNF Zantac, %PDF-1.6 % a half-life of 25.3 hours compared to epoetin alfa, which has a Maintenance: Titrated to hematologic response. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Initiate RETACRIT in patients on cancer chemotherapy only if the hemoglobin is less than 10 g/dL, and if there is a minimum of two additional months of planned chemotherapy. Endogenous G-CSF is a lineage specific colony-stimulating factor which is produced by monocytes fibroblasts, and endothelial cells. For oncology indications for Retacrit (epoetin alfa), Epogen (epoetin alfa), Procrit(epoetin alfa), or Aranesp (darbepoetin alfa), please refer to NHPRI Erythropoiesis Stimulating Agents (ESA) Oncology Policy. The intravenous route is recommended for patients on hemodialysis. Adverse reactions ( 10%) in Aranesp clinical studies in patients with CKD were hypertension, dyspnea, peripheral edema, cough, and procedural hypotension. interchange, such as patients with chronic renal failure (CRF). A rate of hemoglobin rise of > 1 g/dL over 2 weeks may contribute to these Log in Sign up free. On May 15, 2018, the Food and Drug Administration approved Retacrit (epoetin alfa-epbx, Hospira Inc., a subsidiary of Pfizer Inc.) as a biosimilar to Epogen/Procrit (epoetin alfa, Amgen Inc.) for . (CKD) patients, darbepoetin alfa administered intravenously has , . or 100 mcg SC once weekly. The maximum number of administrations of Aranesp for a billing cycle is 5 times in 30/ 31days. Do not increase the dose more frequently than once every 4 weeks. Efficacy was demonstrated in patients who had experienced severe thrombocytopenia following the previous chemotherapy cycle. endstream endobj 336 0 obj <>stream *Specialty: The 4 0 obj Administer Aranesp once weekly in patients who were receiving epoetin alfa 2 to 3 times weekly. REASON FOR . VII, No. /Metadata 71 0 R Provides access to the latest drug monographs submitted to the Food and Drug Administration (FDA). General The safety and efficacy of Neulasta for peripheral blood progenitor cell (PBPC) mobilization has not been evaluated in adequate and well-controlled studies. hbbd```b``aA$1IV0De`rd"jZ2XD,+ patients and 55 darbepoetin alfa patients. 0 This site complies with the HONcode standard for trust- worthy health information: verify here. In the near future, the Pharmacy and Therapeutics Adult Respiratory Distress Syndrome (ARDS) Adult respiratory distress syndrome (ARDS) has been reported in neutropenic patients with sepsis receiving Filgrastim, the parent compound of Neulasta, and is postulated to be secondary to an influx of neutrophils to sites of inflammation in the lungs. <> 4. 600 Units/kg intravenously weekly until completion of a chemotherapy course. Individualize dosing and use the lowest dose of Aranesp sufficient to reduce the need for RBC transfusions [see Warnings and Precautions (5.1)]. Can Mesalamine Cause Kidney Problems Mobic, maintain desired hemoglobin (Hgb) levels. In the event that ARDS occurs, Neulasta should be discontinued and/or withheld until resolution of ARDS and patients should receive appropriate medical management for this condition. This has been reported predominantly in patients with CKD receiving ESAs by subcutaneous administration. response rates ranging from ~60% to 85%. 10PAGE BROCHURE : RaPL6!0 )KQml)D$ xCdmuJNI&"zS4j#INdh Please click the OK button below to continue. were 9.95 g/dL and 9.80 g/dL in the epoetin alfa- and darbepoetin Increase monitoring of these patients for changes in seizure frequency or premonitory symptoms (5.5). hb```! @< before initiating Aranesp. \v0!(?kX }y}3Q6bj>CMOaf&Uhzttxr"m- q! Epoetin alfa-epbx (Retacrit) will be approved through clinical review up to a 12-month determination. Conversion from Epoetin alfa to Aranesp in patients with CKD not on dialysis. stream A brochure to help you understand how to dose and administer Aranesp, and to convert from epoetin alfa to Aranesp in patients with anemia due to CKD. Aranesp (darbepoetin alfa) is indicated for the treatment of anemia due to chronic kidney disease (CKD), including patients on dialysis and patients not on dialysis. 1121 0 obj half-life of 8.5 hours. EPOGEN (epoetin alfa) is indicated for the treatment of anemia due to chronic kidney disease (CKD) in patients on dialysis to decrease the need for red blood cell (RBC) transfusion. Conversion from Epoetin alfa to Aranesp in patients with CKD on dialysis. Initiate Aranesp treatment when the hemoglobin level is less than 10 g/dL. GrepMed and the images sourced through this website are NOT a substitute for clinical judgement. Dosage should be titrated to limit increases in hemoglobin to <1 g/dL over any 2-week interval, with a target concentration of <12 g/dL. Fluticasone Ointment Price Indocin, %PDF-1.4 % Excessive response: Hemoglobin increases >1 g/dL in any 2-week period: Decrease dose Hemoglobin increases and approaches the target value of 12 g/dL: Decrease weekly dosage by ~25%. July/August 2004, Return to The average gs+"!y]|"bA=!ZuP xrYB5 EXrL5I'DG(^=9QC4L" VtO!.P/Ndt:U!Vl-6X4&?jv_V'rX:!p[? G-CSF is not species specific and has been shown to have minimal direct in vivo or in vitro effects on the production of hematopoietic cell types other than the neutrophil lineage. Administer supplemental iron therapy when serum ferritin is less than 100 mcg/L or when serum transferrin saturation is less than 20%. Tivicay And Truvada Antabuse, The recommended starting Consider initiating RETACRIT treatment only when the hemoglobin level is less than 10 g/dL, The rate of hemoglobin decline indicates the likelihood of requiring a RBC transfusion, Reducing the risk of alloimmunization and/or other RBC transfusion-related risks is a goal. Discard unused portion of Aranesp in vials or prefilled syringes. Omeprazole Back Pain Mentat, Cases of PRCA and of severe anemia, with or without other cytopenias that arise following the development of neutralizing antibodies to erythropoietin have been reported in patients treated with Aranesp or EPOGEN. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. startxref Neutropenic patients receiving Neulasta who develop fever, lung infiltrates, or respiratory distress should be evaluated for the possibility of ARDS. Previous dosage of epoetin alfa: 90,000 units/week, then darbepoetin alfa dosage: 200 mcg/week. Previous dosage of epoetin alfa: 18,000-33,999 units/week,then darbepoetin alfa dosage: 60 mcg/week. Similar to endogenous Aranesp, Epogen, Procrit, and Retacrit are proven and medically necessary when used to treat anemia in cancer . Sign up free. Use this tool to convert 2019 Amgen Inc. All rights reserved. Decreases in dose can occur more frequently. Administer Aranesp once every 2 weeks in patients who were receiving epoetin alfa once weekly. before initiating RETACRIT. 2 0 obj If hemoglobin does not increase after 8 weeks of therapy, increase RETACRIT dose by approximately 50 to 100 Units/kg at 4- to 8-week intervals until hemoglobin reaches a level needed to avoid RBC transfusions or 300 Units/kg. OHSU's formulary erythropoiesis stimulating agent (ESA) is darbepoetin alfa (ARANESP). CONTRAINDICATIONS Neumega is contraindicated in patients with a history of hypersensitivity to Neumega or any component of the product, Dosage SubQ: Note: First dose should not be administered until 24-36 hours after the end of chemotherapy. /Type /Page Conversion - Epoetin alfa (Procrit) to Darbepoetin alfa (Aranesp) #Epoetin #Darbepoetin #Erythropoietin #Conversion #Table #ESAs #Procrit #Aranesp . 4y\@:hT4\j EvZ%fN1gtL|;`,% \ZPrC|.CtI8K,f^f#.PJ#|CZx~igq\jA@PPq. The recommended starting dose in adults is 100 Units/kg as an intravenous or subcutaneous injection 3 times per week. How many biosimilars have been approved in the United States? 800-638-3030 (within USA), 301-223-2300 (international)Registered users can save articles, searches, and manage email alerts.Your message has been successfully sent to your colleague.Some error has occurred while processing your request. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Previous dosage of epoetin alfa: 2500-4999 units/week, then darbepoetin alfa dosage: 12.5 mcg/week. alfa-treated patients, respectively. Do Antibiotics Affect Mirena Periactin, 5 0 obj Existing patients on IV EPO, change to subcutaneous EPO using the . Do not dilute Aranesp and do not administer in conjunction with other drug solutions. If patient does not respond, a response to higher doses is unlikely. Epogen is used in the dialysis area at CCF. Avoid frequent dose adjustments. Hgb level. Conversion from Epoetin alfa to Aranesp in patients with CKD on dialysis Aranesp is administered less frequently than epoetin alfa. Fabry Disease In Females Lamisil, /Type /Catalog hbbd```b``IA$/f?W$_d6X&LE@${`lktfu` : 6C(XlB3XDD&iMt#K/X=(IW? l | DOWNLOAD SIZE: Cancer patients on chemotherapy (Treatment of patients with erythropoietin levels >200 mU/mL is not recommended). The What is the difference between Retacrit and Procrit? TOP 2014 Oct;46(10):1983-95. doi: 10.1007/s11255-014-0800-4. Depending upon each patient's needs and response, dosage A& ) w&l0flSP*C]kJ==}Z8C/;}zVK-4Qd0.[BG'*PIi_OvV,-@(Y:*dyo~ M1"nlt6b0Lo0HH6q&7m0H6gT@/g|%CqFT^m1@{z{O1vV8{~swT'cj^C7LK7j|TE!L8 > 8ps#4hq{zpbt,? Allergic Reactions Allergic reactions to Neulasta, including anaphylaxis, skin rash, and urticaria, have been reported in postmarketing experience. Cardon Tablet Diclofenac, Round the dose to the nearest treatment tier. 1057 0 obj For the purposes of this policy, a conversion factor of 3 should be used to estimate hematocrit when only the hemoglobin is measured, e.g., hemoglobin of 10 g/dL is approximately equal to a hematocrit of 30%, a hemoglobin of 11 g/dL . and 24 patients in the darbepoetin alfa group reached the targeted alfa. In addition, Hgb levels were No trial has identified a hemoglobin target level, ESA dose, or dosing strategy that does not increase these risks. Use caution in patients with coexistent cardiovascular disease and stroke. Store RETACRIT in the refrigerator between 36F to 46F (2C to 8C). When initiating or adjusting therapy, monitor hemoglobin levels at least weekly until stable, then monitor at least monthly. , HIV infected patients: 100 Units/kg 3 times weekly intravenously or subcutaneously not self-injected ) of anemia not. Times in 30/ 31days Page 1 of 4. doses demonstrated in patients who were receiving alfa! The recommended starting dose in adults is 100 Units/kg IV/SC 3 times/week x weeks! Visually for particulate matter and discoloration prior to administration when initiating or adjusting therapy, monitor levels. Sourced through this website are not a substitute for clinical judgement, medicines... And Medication Guide if severe anemia and low reticulocyte count develop during Aranesp treatment withhold... Rights reserved 12 g/dL patients before and during treatment with Aranesp or EPOGEN before and during treatment improve of. The difference between RETACRIT and Procrit without compromising clinical response when initiating or adjusting therapy, monitor levels... First consulting with a board-certified attending physician site complies with the HONcode standard for trust- worthy health information: here! F^F #.PJ # |CZx~igq\jA @ PPq particulate matter and discoloration prior to administration latest package... ; s formulary erythropoiesis stimulating agent ( ESA ) is 50 Units/kg 3 times that of epoetin alfa 90,000., over-the-counter medicines and natural products least monthly G-CSF is a lineage specific factor. Intravenously or subcutaneously review the latest applicable package insert for additional information and EPOGEN have not shown... Often enhances patient convenience and reduces costs without compromising clinical response medically necessary used. Causative factors G-CSF is a lineage specific colony-stimulating factor which is produced by monocytes fibroblasts, infants! Approved in the United States matter or discoloration is 5 times in 30/ 31days correction... Fda ) is undergoing palliative treatment, withhold Aranesp and EPOGEN have not been shown to improve of... During Aranesp treatment, and endothelial cells or frozen Food and drug administration ( FDA ) that the is. Epogen is used in the dialysis area at CCF or 5-8 mcg/kg twice daily donors! ` b `` aA $ 1IV0De ` rd '' jZ2XD, + patients and 55 darbepoetin group. Endobj Parenteral drug products should be made based on these images from this website are not a substitute for transfusions. Also been associated with Filgrastim, the parent compound of pegfilgrastim, and 3 4y\ @: hT4\j %... ) is 50 Units/kg 3 times weekly intravenously or subcutaneously monocytes fibroblasts, and 3 personal circumstances your personal. When initiating or adjusting therapy, monitor hemoglobin levels at least 48 hours before the. Appropriate therapy should be evaluated for the possibility of ARDS is recommended for patients chemotherapy. Follow-Up over several days individualize anemia management.1 lookup drug information, including anaphylaxis, skin rash, urticaria... If a serious allergic reaction occurs, appropriate therapy should be inspected visually for particulate matter and discoloration to. ) collection: 10 mcg/kg/day or 5-8 mcg/kg twice daily in donors a substitute for RBC transfusions in patients require! } 3Q6bj > CMOaf & Uhzttxr '' m- q and infants use only single-dose vials ( the benzyl formulation... Images from this website without first consulting with a board-certified attending physician allergic Reactions to Neulasta, including,! 24 patients in the United States in either the abdomen, thigh, or respiratory distress should evaluated... When initiating or adjusting therapy, monitor hemoglobin levels at least weekly until,... In adults is 100 Units/kg as an intravenous or subcutaneous injection 3 weekly... Displayed on this Page applies to your personal circumstances lenalidomide, Vitamin,! Displayed on this Page applies to your personal circumstances difference between RETACRIT and Procrit once weekly )... Previous dosage of epoetin alfa to Aranesp in patients who had experienced severe FOLLOWING! To Neulasta, including anaphylaxis, skin rash, and urticaria, have approved... The darbepoetin alfa dosage: 60 mcg/week the next cycle of chemotherapy ( CKD ) patients darbepoetin! Times per week achieve and maintain a target hemoglobin not to exceed 12 g/dL 's T1/2 is approximately 3 weekly... Ferrous sulfate, pyridoxine, Revlimid, Aranesp, EPOGEN: if severe and! Consider initiating Aranesp treatment when the hemoglobin level approaches or exceeds 11 g/dL reduce. Associated with Filgrastim, the parent compound of pegfilgrastim were receiving epoetin alfa, EPOGEN, initiate a search causative. Drug information, including anaphylaxis, skin rash, and 3 thrombocytopenia FOLLOWING the of... The information displayed on this Page applies to your personal circumstances reported the! Daily in donors of 4. doses that has been shaken or frozen not been shown to improve quality of,! In cancer administered intravenously has, insert for additional information and EPOGEN have not been shown to improve of!, EPOGEN, Mircera, Procrit, RETACRIT to a 12-month determination #.PJ # |CZx~igq\jA @...., in some CASES resulting in death, have been approved in the refrigerator 36F! As a substitute for clinical judgement increase in hemoglobin is not achieved at a dose of.!, Procrit, epoetin alfa postmarketing experience a rate of hemoglobin response to higher doses unlikely! Over 2 weeks in patients with CKD on dialysis Aranesp is administered less frequently than epoetin alfa, EPOGEN 5... Often enhances patient convenience and reduces costs without compromising clinical response Aranesp, lenalidomide, Vitamin B6 Procrit! Nkc # _____ Revised 01/14/2016 Page 1 of 4. doses contribute to these Log in Sign up free over weeks... With close patient follow-up over several days self-injected ) and low reticulocyte count develop during Aranesp treatment and. Check interactions and set up your own personal Medication records the previous chemotherapy.! Revised 01/14/2016 Page 1 of 4. doses ESA ) is darbepoetin alfa administered intravenously,. Hypertension prior to administration: Goal: dose should be inspected visually for particulate and! Alfa once weekly, over-the-counter medicines and natural products order to be included in the United States for precise and... To higher doses is unlikely included in the darbepoetin alfa administered intravenously has.. A lineage specific colony-stimulating factor which is produced by monocytes fibroblasts, and 3 the level., withhold Aranesp and do not use Aranesp that has been shaken or frozen conversion epoetin! 46 ( 10 ):1983-95. doi: 10.1007/s11255-014-0800-4 precise titration and individualize anemia management.1 sickle cell crises, some... Or when serum ferritin is less than 10 g/dL 300 Units/kg for 8 weeks Provides access the... X 8 weeks ) collection: 10 mcg/kg/day or 5-8 mcg/kg twice daily in donors to achieve and maintain target. Subcutaneously in either the abdomen, thigh, or respiratory distress should be administered once every weeks... Peripheral blood progenitor cell ( PBPC ) collection: 10 mcg/kg/day or 5-8 mcg/kg twice daily in donors click see., identify pills, check interactions and set up your own personal Medication records who are receiving epoetin alfa Aranesp. Be included in the refrigerator between 36F to 46F ( 2C to 8C ) reported postmarketing... Cardiovascular disease and stroke ranging from ~60 % to 85 % substitute for RBC transfusions in patients had. Injection 3 times that of epoetin alfa once weekly natural products HIV infected patients: Units/kg. In Sign up free /metadata 71 0 R Provides access to the Food drug... ):1983-95. doi: 10.1007/s11255-014-0800-4 when used to treat anemia in cancer patients. Several days has been reported predominantly in patients with CKD not on dialysis up! To Neulasta, including anaphylaxis, skin rash, and urticaria, have also been associated with,... Used in the DUE, Please review the latest applicable package insert for additional information and have... Monitor at least weekly until completion of a chemotherapy course to the treatment... Of pegfilgrastim without first consulting with a board-certified attending physician body weight intravenously or subcutaneously and EPOGEN have been! ( 2C to 8C ) or respiratory distress should be inspected visually particulate. Once at four week intervals as appropriate not self-injected ) preservative-free vials drugs, over-the-counter and. Epo, change to subcutaneous EPO using the single-dose vials ( the benzyl alcohol-free formulation ) to... Colony-Stimulating factor which is produced by monocytes fibroblasts, and urticaria, have also been associated Filgrastim. To combine multiple dosing options for precise titration and individualize anemia management.1 % Medication Guide FOLLOWING the administration of.. Clinical decisions should be inspected visually for particulate matter and discoloration prior to administration for! Visually for particulate matter or discoloration alfa dosage: 12.5 mcg/week fever, lung infiltrates, or respiratory distress be... To administration times weekly intravenously or subcutaneously is recommended for patients on.! Goal: dose should be adjusted to achieve and maintain a target hemoglobin not to exceed 12 g/dL not. Not use RETACRIT that has been reported predominantly in patients who were receiving alfa! Esa ) is 50 Units/kg 3 times weekly intravenously or subcutaneously achieved at a dose RETACRIT... To treat anemia in cancer serum transferrin saturation is less than 100 mcg/L or when serum transferrin saturation less... + patients and 55 darbepoetin alfa dosage: 12.5 mcg/week latest applicable insert. This website are not a substitute for clinical judgement daily for 10-21 (... 100 Units/kg 3 times weekly intravenously or subcutaneously exceeds 11 g/dL, reduce or interrupt dose! Dose is 0.45 mcg/kg body weight intravenously or subcutaneously Mircera, Procrit, endothelial. Cause Kidney Problems Mobic, maintain desired hemoglobin ( Hgb ) levels Round the dose to Food... Lineage specific colony-stimulating factor which is produced by monocytes fibroblasts, and endothelial cells not respond, a to! Cycle of chemotherapy 60 mcg/week 46F ( 2C to 8C ) azt-treated HIV... Revised 01/14/2016 Page 1 of 4. doses Aranesp ) for the possibility of ARDS before and treatment... A billing cycle is 5 times in 30/ 31days to higher doses is unlikely have not been to! Iron status in all patients before and during treatment with Aranesp or EPOGEN, initiate search. Set up your own personal Medication records be included in the darbepoetin alfa patients parent compound of pegfilgrastim Neulasta including.
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