A response was defined as a reduction of at least 50 percent in the corticosteroid dose, a decrease of at least 25 percent in the serum IgE concentration, and one of the following: an improvement of at least 25 percent in exercise tolerance or pulmonary-function tests or resolution or absence of pulmonary infiltrates. The relative binding affinity that progesterone and its metabolites display for PBP correlates with the relative growth inhibitory potency of these compounds. The infants had been hospitalized for at least six weeks, had received broad-spectrum antibiotics, and had received parenteral lipid nutrition via a central venous catheter. A pool of 96 clinical isolates consisting of 50 azole-resistant or susceptible dose-dependent isolates and 46 azole-susceptible isolates was screened by PCR for the presence of MTLa1 and MTLalpha1. Therapy is predominantly directed at preventing life-threatening hemoptysis. Animal models of infection are invaluable tools in studies of pathogenesis, immunological response, and for the testing of experimental therapeutics, which cannot be done in humans. Phylogenetic species were genetically distinct with interspecific divergence 4-fold greater than intraspecific divergence and a high Fst value (0.772, P<0.001) indicative of restricted gene flow between PS1 and PS2. After a long period of relative inactivity in the introduction of new antifungals, more recently a few new drugs of already existing classes have been introduced. View details for DOI 10.1016/j.micinf.2003.12.010, View details for Web of Science ID 000220770600006. A similar setup has existed in Denmark and Sweden for years. Help keep Alice Roberts profile up to date. View details for Web of Science ID 000179144900023. Since macrophage production of TNF-alpha is an important innate immune response, we examined a mouse peritoneal macrophage (PM) cell line (RAW) and resident PM from CD-1 mice to study TNF-alpha production by PM stimulated with heat-killed (HK) or live B. dermatitidis yeast cells. What position the state should take with regards to religious and other comprehensive claims. Alice Roberts and David Stevens have been mar See View details for DOI 10.1128/IAI.72.8.4878-4880.2004, View details for Web of Science ID 000222932600066. Social justice. View details for DOI 10.1007/978-1-61779-539-8_41. Most cases were caused by Aspergillus fumigatus. Typing by restriction fragment length polymorphism (RFLP) revealed all blood isolates were RFLP subtype VII-1. Only two of six patients who were treated with antifungal agents survived endocarditis caused by T. beigelii and were apparently cured; one of these patients was also managed surgically with valve replacement. The elder Mazar was a Jew born in . View details for Web of Science ID A1992HA14300012. He believes that we must harness the human mind, especially working in focused groups, as the greatest resource available in the development of businesses and projects. Morton, C. O., Clemons, K. V., Springer, J., Mueller, J. G., Rogers, T. R., Stevens, D. A., Kurzai, O., Einsele, H., Loeffler, J. Pharmacokinetics of voriconazole in adult mallard ducks (Anas platyrhynchos). View details for Web of Science ID A1988Q160000035, View details for PubMedCentralID PMC266826. Walsh, T. J., Raad, I., Patterson, T. F., Chandrasekar, P., Donowitz, G. R., Graybill, R., Greene, R. E., Hachem, R., Hadley, S., Herbrecht, R., Langston, A., Louie, A., Ribaud, P., Segal, B. H., Stevens, D. A., van Burik, J. H., White, C. S., Corcoran, G., Gogate, J., Krishna, G., Pedicone, L., Hardalo, C., Perfect, J. R. Experimental animal models of coccidioidomycosis. Little is known, however, about the most appropriate dosage and schedule of administration. Most of these clinical isolates are able to grow at 42 degrees, a temperature that completely inhibits the growth of most other S. cerevisiae strains. The effect of human sera was further seen when using caspofungin that had lost activity (e.g., by storage) against A. fumigatus at 0.1 microg/ml. View details for DOI 10.3109/1040841X.2011.581223, View details for Web of Science ID 000295616800001. View details for DOI 10.1016/j.diagmicrobio.2008.04.019, View details for Web of Science ID 000258994000018. Animal models testing monotherapy versus combination antifungal therapy: lessons learned and future directions, Development of an orogastrointestinal mucosal model of candidiasis with dissemination to visceral organs. BAM from CD-1 mice were stimulated with B. dermatitidis without or with normal BALF, surfactant protein A-deficient (SP-A-/-) or surfactant protein D-deficient (SP-D-/-) BALF, or a mixture of SP-A-/- and SP-D-/- BALF. Our objectives were to determine pharmacokinetic parameters and evaluate efficacy of voriconazole (VCZ) in a novel experimental quail model. Starting 5 days postinfection, animals received one of the following: 5% dextrose water diluent; AMB given at 1 mg/kg of body weight; AmBi given at 7.5, 15, or 22.5 mg/kg intravenously three times per week for 3 weeks; or oral FLC given at 80 mg/kg for 19 days. Often, making television documentaries can be very un-family-friendly work. View details for DOI 10.1080/13693780500220498, View details for Web of Science ID 000235382600007. Epidemiological studies indicate a striking rarity of disease (but not infection) in females, but only during the reproductive years. MMP-9 promotes inflammation, breakdown of the blood-brain barrier, and vasculitis. We evaluated the immunomodulatory effects of three different classes of antifungal agents on the human monocytic cell line, THP-1, which had been stimulated in vitro with Aspergillus fumigatus conidia. Combinations of AmBi plus CAS or MICA prolonged survival, but were not better than monotherapy. We also found that one commercial strain was indistinguishable from the strain isolated from three different women at the time that they were suffering from vaginitis. GM-CSF given 24 h before DEX resulted in blocking of DEX suppression of BAM conidiacidal activity. Global population structure of Aspergillus terreus inferred by ISSR typing reveals geographical subclustering. In basilar arteries of infected animals versus controls, mRNAs encoding for IL-6, iNOS, IFN-gamma, IL-2, MCP-1, IL-1beta, IL-10, TNF-alpha, CCR-1, MMP-9, TGF-beta, as well as MMP-9 protein in CSF, were found to be significantly up-regulated. [5], After promoting Reading Museum for over a decade, on the 20 August 1891 in Reading Town Hall, Stevens was presented his own marble bust which had been commissioned in his honour and paid for by public subscription. She completed a PhD in Egyptian Archaeology at Monash Uni versity in Australia in 2003, with a study of the archaeology of private religion at Amarna . After infection spleen cells from IL-12 treated mice produced 4-fold more IFN-gamma and 3-fold less IL-10 in response to Blastomyces. The aim of the present investigation was to assess the epidemiological relatedness of a group of vaginal and commercial S. cerevisiae isolates by a previously reported genetic typing method, which divided the isolates into two broad groups with numerous subtypes. IL-4, IL-6, and gamma interferon transcripts were detected on day 5, and IL-1 beta and IL-10 transcripts were detected beginning on day 7. > present (Member of the Advisory Board of the Cheltenham Festival of Science) and [????] 1,398 Followers, 664 Following, 206 Posts - See Instagram photos and videos from DAVID STEVENS | Photographer (@davidstevens.photo) Managing Director, Maunsell Management, Hong Kong. Southern analysis and single nucleotide polymorphism (SNP) analysis were used to determine that this loss of heterogeneity was due to replacement of one of the MTL loci with a duplicate of the other locus resulting in two homozygous copies of the MTL locus. David Stevens (Gojiboy) See Photos. "With just one profound discovery, mankind's entire story could change," so said Megan Fox in . Studies of the paradoxical effect of caspofungin at high drug concentrations. Five infected and 3 sham-injected rabbits at each time point were euthanized 4, 9, 14 and 20 days post infection. Available at: , School of Politics and International Relations. The median duration of treatment was 173 days. The brain and spinal cord contained the highest concentrations of fungal DNA. WT and KO mice were dose-responsively susceptible. Nicola Harrington told National Geographic, "the cones (were) worn in the presence of the divine," she said. It seemed like an obvious choice, and I dont think he struggled with it. PCR has been made specific by genus-specific probes, with 100% sensitivity and reasonable specificity. The results of histopathologic analysis were unremarkable. > present (Member of the Advisory Board of the Cheltenham Festival of Science), [????] Bronchial artery embolization rarely produces a permanent success, but may be useful as a temporizing procedure in patients with life-threatening hemoptysis. Liked by David Stevens. The AAC workshop identified savings of HK$1.4 billion in three days for a project in Hong Kong; 80 million for another in England in one day; more than Aus$70 million in two days for an airport in Australia. Since 2019, she has been President of the charity Humanists UK, which campaigns for state secularism and for "a tolerant world where rational thinking and kindness prevail". The estimates for the mean (standard deviation) for clearance and the volume of the central compartment were 1.60 (0.85) liter/h and 20.61 (15.27) liters, respectively. No monotherapy or combination regimen showed superiority for the treatment of pulmonary aspergillosis in corticosteroid suppressed mice and the potential for combined drug toxicity was enhanced in these mice. Stevens, D. A., Hamilton, J. R., Johnson, N., Kim, K. K., Lee, J. Only the 40-mg/kg dose of VCZ was effective. If you made any changes in Pure these will be visible here soon. Mice were infected intracranially and treated for 4 days with CAS (1, 5, or 10 mg/kg of body weight/day) or amphotericin B (AMB) (3 mg/kg/day) starting 1 day postinfection. These various manifestations of the diseases, diagnosis and treatment are organized for basic scientists, so that they may better understand the dimensions and nature of the clinical challenges. With both the MTT and XTT assays, neutrophils alone inhibited hyphae; when combined with VCZ, there was additive activity. Little is known about the effect of surfactant-associated proteins in bronchoalveolar lavage fluid (BALF) on the interaction of BAM and Blastomyces dermatitidis. View details for DOI 10.1128/AAC.50.4.1293-1297.2006, View details for Web of Science ID 000236685700025. The first cohort received 3 mg of liposomal amphotericin B/kg of body weight/day; the second cohort received 10 mg of liposomal amphotericin B/kg at time zero, followed by 5 mg/kg at 48 and 120 h. The levels of liposomal amphotericin B were measured by high-pressure liquid chromatography (HPLC). The pharmacokinetics for both conventional and intermittent dosing were linear. [1] He took up his own archaeological digs and eventually found Palaeolithic implements in the Reading drift gravels and excavated sites at Gas Works Lane and at Cemetery Junction in Reading. Random mating among PS1 isolates, which were distributed across North America, was only detected after partitioning isolates into six geographic regions. Neal, C. O., Richardson, A. O., Hurst, S. F., Tortorano, A. M., Viviani, M. A., Stevens, D. A., Balajee, S. A. Real-time PCR and quantitative culture for monitoring of experimental Aspergillus fumigatus intracranial infection in neutropenic mice. There was no apparent relation between dose, time after dose, site of CSF sampling, or concurrent inflammation and CSF ketoconazole concentration. van Asbeck, E. C., Huang, Y., Markham, A. N., Clemons, K. V., Stevens, D. A. Five types of murine models are studied and include primary pulmonary disease, intraperitoneal with dissemination, intravenous infection emulating systemic disease, and intracranial or intrathecal infection emulating meningeal disease. This property can be considered a virulence trait and may help explain the presence of these isolates in human hosts. At equivalent doses of 50 mg/kg of body weight, RCZ and ITZ were equally effective and RCZ was more effective than FCZ (P = 0.02). Combination therapy using available drugs is an attractive choice, yet primarily only anecdotal clinical data are available. I am especially interested in how material culture and urban space can shed light on the lives of the non-elite in ancient Egypt. View details for Web of Science ID 000166958800032. More young children have wandered into the pop-up store. In summary, these data indicate that the risk factor for aspergillosis associated with DEX could be lessened in the pulmonary compartment with GM-CSF. Shankar, J., Wu, T. D., Clemons, K. V., Monteiro, J. P., Mirels, L. F., Stevens, D. A. The decision to taper steroids should be made on an individual basis, depending on clinical course. Sabino, R., Carolino, E., Moss, R. B., Banaei, N., Verissimo, C., Stevens, D. A. Halomonas johnsoniae: review of a medically underappreciated genus of growing human importance. Join Facebook to connect with Dave Stevens and others you may know. TNFalpha production by young macrophages (BAM or PM), when cocultured with Bd for 18 h, was half of TNFalpha secreted by adult macrophages. My husband [field archaeologist David Stevens] took on the role of primary carer when we were filming, and he came with me on all the shoots. British Writer David Stevens was born on 17th July, 1940 in Tiberias, Palestine and passed away on 17th Jul 2018 Whangarei, New Zealand aged 78. The importance of C5 was confirmed by studies using B10.D2/oSnJ (C5-) mice and their congenic C5+ counterparts. There have been several reports that the activity of echinocandin antifungal agents is not affected or decreased in the presence of human sera. Paracoccidioides is the causative agent of paracoccidioidomycosis, a systemic mycosis endemic to Latin America. The laboratory is, in addition, a clinical reference laboratory for fungal and actinomycete susceptibility testing, and body fluid antifungal drug concentration determinations, for hospitals. Improvement was noted with amphotericin B or itraconazole followed by voriconazole but not with itraconazole followed by amphotericin B. She is especially interested in how material culture and urban space can shed light on the lives of the non-elite in ancient Egypt. Additional studies are warranted. Overall, we found that HKY protects mice from infection by Candida albicans in a dose-and regimen-dependent manner. Clemons, K. V., Parmar, R., Martinez, M., Stevens, D. A. We have previously described differences in phenotype and virulence among clinical and nonclinical isolates of Saccharomyces. Evidence from the existing literature was graded, and the consensus views were synthesized into this document and recirculated for affirmation. The use of AmBi with CAS or VCZ at optimal doses did not improve efficacy. The availability of genetically defined strains of mice, immunological reagents, cost and ease of handling are factors. By complying with the current policies and regulations, the risks from these programs can be minimized. In the first study, mice were infected intracerebrally with 2.1 x 10(6) conidia/mouse of Aspergillus fumigatus; 10 days of once daily therapy began one day later. Connect with the University of Nottingham through social media and our blogs. A model was used to compare the efficacies of itraconazole and fluconazole. Zucker, K. E., Kamberi, P., Sobel, R. A., Cloud, G., Meli, D. N., Clemons, K. V., Stevens, D. A., Williams, P. L., Leib, S. L. Efficacy of micafungin alone or in combination against experimental pulmonary aspergillosis, Susceptibility to pulmonary blastomycosis in young compared to adult mice: immune deficiencies in young mice. ACU Trooper at Jurassic World. | Art UK", https://en.wikipedia.org/w/index.php?title=Joseph_Stevens_(archaeologist)&oldid=1084872919, This page was last edited on 27 April 2022, at 03:03. These data suggest that it may be possible to suppress lymphocyte responses with DEX, yet at the same time maintain BAM defenses with GM-CSF against pulmonary infections by conidia of A. fumigatus. All treatments prolonged survival (P = 0.005) and reduced cfu in brain and spinal cord (P > present (Science columnist for The Observer newspaper), 2018 > present (president of Humanists UK), 2011 > present (patron of Humanists UK), 2012 > present (Chair of the Birmingham universitys Public Engagement with Science Committee), [????] Fungicidal activity of peripheral blood polymorphonuclear neutrophils (PMN) from CD-1 (87%) was greater than that of BALB/c (75%) (P<0.05). Invasive fungal diseases (IFDs) have become major causes of morbidity and mortality among highly immunocompromised patients. Catanzaro, A., Cloud, G. A., Stevens, D. A., Levine, B. E., Williams, P. L., Johnson, R. H., Rendon, A., Mirels, L. F., Lutz, J. E., Holloway, M., Galgiani, J. N. Posaconazole therapy for chronic refractory coccidioidomycosis. This methodology, applied to species of Saccharomyces, allows unknown Saccharomyces isolates to be assigned to the type strains. There were 14 blood culture and nine colonizing isolates from other sites available. Initial attempts at environmental isolation as primary cultures, including a 4% salt agar plate, or initial incubation in 6.5% salt broth enrichment culture with subculture to agar, to exploit the halophilicity of Halomonas, were successful in demonstrating the colonies seen in the blood cultures, only from sites not contaminated with other organisms, because of competing growth. Future work can focus on evaluation of MMP inhibitors, to gain a better perspective of the role of this MMP in CM. View details for Web of Science ID 000226559700009. All drug regimens prolonged survival (P < or = 0.0008) and reduced cfu (P < or = 0.0001-0.003) recovered from the brains and kidneys compared with untreated. View details for Web of Science ID 000220735200015. Although GM-CSF did not enhance IL-1 or TNF production by BAM+conidia, GM-CSF significantly antagonized DEX suppression of IL-1 cytokine production. Therapeutic and toxicologic studies in a murine model of invasive pulmonary aspergillosis, Microsatellite multilocus genotyping clarifies the relationship of Candida parapsilosis strains involved in a neonatal intensive care unit outbreak. Rabbits have been used to study IPA and systemic disease, as well as fungal keratitis. View details for Web of Science ID A1988N738500008. The molecular epidemiology of Candida dubliniensis has been studied using large complex DNA probes for Southern analysis and has revealed the existence of distinct genotypes within this species. Alice Roberts is a 49 year old British TV Personality. Brains from surviving mice had CFU of Aspergillus fumigatus. The workshops that David Stevens has run for us on three PFI Hospitals projects have on each occasion proved to be an essential catalyst for identifying the critical issues, slaughtering the sacred cows and improving the value for money of the project whilst improving the overall effectiveness of the team., Dr Richard Baldwin, Managing Director, Special Projects, Alfred McAlpine, UK, As an international organisation involved in the corporate area we have seen the highly successful application of Dr Stevens Big Project techniques on a wide range of small and medium sized businesses. Allergic bronchopulmonary aspergillosis is a hypersensitivity disorder that can progress from an acute phase to chronic disease. The effect of trypanosomiasis on human cardiac stem cells is also being explored (in collaboration with Cardiovascular Medicine at Stanford).Current efforts concern study of a model of respiratory tree aspergillosis, to understand the predilection of lung transplant patients to invasive disease (in collaboration with the Div. By Candida albicans in a dose-and regimen-dependent manner these data indicate that the activity of antifungal! Differences in phenotype and virulence among clinical and nonclinical isolates of Saccharomyces, allows unknown isolates. Drug concentrations N., Clemons, K. V., Parmar, R.,,! Correlates with the current policies and regulations, the risks from these programs can be minimized in the presence human. In Pure these will be visible here soon Kim, K. K., Lee, J the state take. These will be visible here soon better than monotherapy Advisory Board of Advisory. And 3-fold less IL-10 in response to Blastomyces and systemic disease, well! 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