In one study 9% of 268 dogs with decreased platelet counts were diagnosed as having either primary ITP or Evans' syndrome (ITP and immune-mediated hemolytic anemia). JVIM 7 (5), 261-265 PubMed. Platelets are made in the bone marrow, their function is to form blood clots. Only 7% of all thrombocytopenic cats showed evidence of hemorrhage from any cause at presentation. Wondratschek C(1), Weingart C, Kohn B. Immunosuppressive doses of prednisone were curative. Immune-mediated thrombocytopenia. Despite this, some patients with IMT are asymptomatic with no evidence of bleeding, whereas others have fever, splenomegaly and other … Platelets are cells required to clot blood and prevent bleeding. All cats were treated with prednisolone; one cat received chlorambucil in addition. Secondary thrombocytopenia: The goal is to find and treat the underlying cause. Two cats in the multiple disease group had a concurrent immune-mediated dis- Corticosteroids to slow down immune-mediated platelet destruction. Treatment of Pituitary Form of Cushing's Syndrome. Immune-mediated thrombocytopenia in dogs can be classified in two categories. Two cats in the multiple disease group had a concurrent immune-mediated dis- Four were positive for FeLV. It has been seen in dogs, horses, and rarely cats. Without adequate functional platelets, patients can spontaneously bleed. ). Corticosteroids to slow down immune-mediated platelet destruction. Primary immune-mediated thrombocytopenia … Immune-mediated thrombocytopenia (IMT) is a relatively common cause of bleeding in small animals, particularly the dog. Transfusion of platelets or whole blood. 2010 Jan-Feb;46(1):12-9. Another 11 had bone marrow disease and 6 had immune-mediated thrombocytopenia.
Also known as idiopathic thrombocytopenic purpura, primary immune-mediated thrombocytopenia is an autoimmune disorder where the antibodies attack portions of the platelet membrane. Thrombocytopenia is a term that refers to a decrease in the number of thrombocytes (also known as platelets) circulating in the blood. Positive tests may be detected, for example, in dogs with rickettsial infections, and in cats with thrombocytopenia associated with feline leukemia virus or antithyroid medications. Identification of Underlying Disease. This cat’s platelet count was one of the lowest ( 1 OOO/pL) of all 4 1 cats. Author information: (1)Clinic for Small Animals, Faculty of Veterinary Medicine, Free University of Berlin, Oertzenweg 19b, Berlin, 14163, Germany. JSAP 40 (3), 127-131 PubMed. Occasionally, cats and dogs develop thrombocytopenia or low platelets, and this condition can be life-threatening. Any severe or prolonged blood loss, increased internal destruction of platelets, or impaired bone marrow production can lead to acute (short-term) or chronic (long-term) deficiency of platelets. Without adequate functional platelets, patients can spontaneously bleed. Thrombocytopenia is a term that refers to a decrease in the number of thrombocytes (also known as platelets) circulating in the blood. Feline Focus 8, 2-7. Thrombocytopenia in Dogs and Cats.
Primary immune-mediated thrombocytopenia (ITP), (also called idiopathic thrombocytopenia or idiopathic thrombocytopenic purpura) is characterized by immune-mediated destruction of either circulating platelets or, less commonly, marrow megakaryocytes. Thrombocytopenia is the most common acquired hemostatic disorder in dogs, and immune mediated thrombocytopenia (ITP) is the most common cause of severe thrombocytopenia. Only 7% of all thrombocytopenic cats showed evidence of hemorrhage from any cause at presentation.
Immune-mediated thrombocytopenia is the term used to describe the destruction of platelets by the body’s immune system. Thrombocytopenia is the most common acquired hemostatic disorder in dogs, and immune mediated thrombocytopenia (ITP) is the most common cause of severe thrombocytopenia.